Bitcoin DeFi Poised for Explosive Growth: 300 Million User Potential

A prominent crypto founder predicts a seismic shift in the DeFi landscape, forecasting that Bitcoin’s decentralized finance ecosystem could attract a staggering 300 million users. This projection surpasses the user bases of Ethereum and Solana, potentially revolutionizing the industry.
Alexei Zamyatin, co-founder of Build on Bitcoin, highlighted the massive untapped potential within Bitcoin’s existing user base. In an interview at TOKEN2049 Dubai, he emphasized the significant advantage of targeting this large retail market: “The advantage of Bitcoin DeFi is that the market is much bigger; you have a far larger retail user base to tap into.”
“If you manage to win in Bitcoin DeFi, you win the entire market.”
Zamyatin’s bold prediction suggests Bitcoin DeFi services will dwarf existing platforms. Build on Bitcoin is actively pursuing this market share, offering a hybrid layer-2 solution using BitVM, a platform designed to process Turing-complete Bitcoin contracts, effectively combining Bitcoin’s security with Ethereum’s DeFi functionality.
He stressed the need for Bitcoin-native bridges, acknowledging Bitcoin’s robust security but highlighting the limitations in human resources, development tools, and network effects compared to Ethereum. The demand for Bitcoin-based DeFi solutions is fueled by a surge in interest for Bitcoin yield and stablecoin products, according to Zamyatin.
He noted that institutional investors, significant buyers of Bitcoin, actively seek yield opportunities, driving demand for Bitcoin yield products. The demand for Bitcoin-backed stablecoins is also booming, largely due to Bitcoin’s status as the premier collateral asset.
What if we tokenized the Bitcoin ETF so institutions could get access to DeFi yields? pic.twitter.com/2HCpwbCZDS
— alexei (@alexeiZamyatin) April 10, 2025
Beyond payments, Bitcoin staking has emerged as a key DeFi use case. Babylon Protocol currently leads this sector, demonstrating significant growth in Bitcoin’s DeFi Total Value Locked (TVL).
While Bitcoin DeFi’s TVL remains significantly smaller than Ethereum’s, Zamyatin’s forecast, coupled with the current trends, suggests a potential for exponential growth. He acknowledged the challenges of bridging solutions and the concerns surrounding security, but highlighted that many bridge failures stem from mismanagement of private keys rather than inherent smart contract vulnerabilities.
Despite the potential, institutional hesitancy toward bridges persists, largely due to concerns about transparency and accountability in the signing process. This emphasizes the need for solutions that address these concerns and accelerate the adoption of Bitcoin DeFi.
Additional reporting by Ezra Reguerra.